Content Category 5E: Principles of chemical thermodynamics and kinetics

The processes that occur in living systems are dynamic, and they follow the principles of chemical thermo-dynamics and kinetics. The position of chemical equilibrium is dictated by the relative energies of products and reactants. The rate at which chemical equilibrium is attained is dictated by a variety of factors: concentration of reactants, temperature, and the amount of catalyst (if any).  

Biological systems have evolved to harness energy and utilize it in very efficient ways to support all processes of life, including homeostasis and anabolism. Biological catalysts, known as enzymes, have evolved to allow all the relevant chemical reactions required to sustain life to occur both rapidly and efficiently, and under the narrow set of conditions required. 

The content in this category covers all principles of chemical thermodynamics and kinetics including enzymatic catalysis. 

Topic Biochemistry Biochemistry: A Short Course Biology, 2e Fundamentals of Biochemistry Human Physiology Karp’s Cell and Molecular Biology Organic Chemistry with a Biological Emphasis, Vol. 1 Organic Chemistry with a Biological Emphasis, Vol. 2
Enzymes (BC, BIO)
  • Classification by reaction type
  • Mechanism
    • Substrates and enzyme specificity
    • Active site model
    • Induced-fit model
    • Cofactors, coenzymes and vitamins
  • Kinetics
    • General (catalysis)
    • Michaelis-Menten
    • Cooperativity
    • Effects of local conditions on enzyme activity
  • Inhibition
  • Regulatory enzymes
    • Allosteric
    • Covalently modified
  • Ch. 8 Enzymes: Basic Concepts and Kinetics, pp. 223-264
  • Ch. 9 Catalytic Strategies, pp. 273-306
  • Ch. 10 Regulatory Strategies, pp. 303-335
  • Ch. 6 Basic Concepts of Enzyme Action, pp. 105-115
  • Ch. 7 Kinetics and Regulation, pp. 119-134
  • Ch. 8 Mechanisms and Inhibitors, pp. 143-156
  • Ch. 17 Enzyme Kinetics, Inhibition, and Control, pp. 346-401
  • Ch. 2 Chemical Composition of the Body, pp. 51-52
  • Ch. 4 Energy and Metabolism, pp. 102-106
  • Ch. 21 The Digestive System, pp. 762-763
  • Ch. 3 Bioenergetics, Enzymes, and Metabolism, pp. 89-100, 106, 109-110
  • Ch. 6.3-6.4, pp. 320-324
  • Ch. 16.5, pp. 355-360
  • Ch. 17.7-17.4, pp. 369-412
Principles of Bioenergetics (BC)
  • Bioenergetics/thermodynamics
    • Free energy/Keq
    • Concentration
  • Phosphorylation/ATP
    • ATP hydrolysis ΔG << 0
    • ATP group transfers
  • Biological oxidation-reduction
    • Half-reactions
    • Soluble electron carriers
    • Flavoproteins
  • Ch. 8 Enzymes: Basic Concepts and Kinetics, pp. 236-239
  • Ch. 15 Metabolism: Basic Concepts and Design, pp. 463-475
  • Ch. 18 Oxidative Phosphorylation, pp. 576-582
  • Ch. 6 Basic Concepts of Enzyme Action, pp. 108-114
  • Ch. 15 Metabolism: Basic Concepts, pp. 286-292
  • Ch. 20 The Electron-Transport Chain, pp. 402-413
  • Ch. 18 Electron Transport and Oxidative Phosphorylation, pp. 588-629
  • Ch. 4 Metabolism, pp. 100-113
  • Ch. 3 Bioenergetics, Enzymes, and Metabolism
  • Ch. 6.2-6.4, pp. 312-324
  • Ch. 9.1-9.6, pp. 4-32
  • Ch. 15.1-15.2, pp. 278-287
  • Ch. 15.4B, pp. 303-307