Content Category 1C: Transmission of heritable information from generation to generation and the processes that increase genetic diversity

The information necessary to direct life functions is contained within discrete nucleotide sequences transmitted from generation to generation by mechanisms that, by nature of their various processes, provide the raw materials for evolution by increasing genetic diversity. Specific sequences of deoxyribonucleic acids store and transfer the heritable information necessary for the continuation of life from one generation to the next. These sequences, called genes ― being part of longer DNA molecules ― are organized, along with various proteins, into biomolecular assemblies called chromosomes.  

Chromosomes pass from parents to offspring in sexually-reproducing organisms. The processes of meiosis and fertilization maintain a species’ chromosomes count during the sexual life cycle. Because parents pass on discrete heritable units that retain their separate identities in offspring, the laws of probability can be used to predict the outcome of some, but not all, genetic crosses.  

The behavior of chromosomes during meiosis and fertilization is responsible for most of the genetic variation that arises each generation. Mechanisms that contribute to this genetic variation include independent assortment of chromosomes, crossing over, and random fertilization. Other mechanisms, such as mutation, random genetic drift, bottlenecks, and immigration, exist with the potential to affect the genetic diversity of individuals and populations. Collectively, the genetic diversity that results from these processes provides the raw material for evolution by natural selection. 

The content in this category covers the mechanisms by which heritable information is transmitted from generation to generation, and the evolutionary processes that generate and act upon genetic variation. 

Topic Biochemistry Biochemistry: A Short Course Biology, 2e Fundamentals of Biochemistry Human Physiology Karp’s Cell and Molecular Biology
Evidence that DNA is Genetic Material (BIO) NA NA
  • Ch. 3 Nucleotides, Nucleic Acids, and Genetic Information: Section 3. Overview of Nucleic Acid Function, pp. 50-53
  • Ch. 2 Chemical Composition of the Body, pp. 52-54
  • Ch. 10 The Nature of the Gene and the Genome, pp. 374-377
Mendelian Concepts (BIO)
  • Phenotype and genotype
  • Gene
  • Locus
  • Allele: single and multiple
  • Homozygosity and heterozygosity
  • Wild-type
  • Recessiveness
  • Complete dominance
  • Co-dominance
  • Incomplete dominance, leakage, penetrance, expressivity
  • Hybridization: viability
  • Gene pool
NA NA NA NA
  • Ch. 10 The Nature of the Gene and the Genome, pp. 366-373
Meiosis and Other Factors Affecting Genetic Variability (BIO)
  • Significance of meiosis
  • Important differences between meiosis and mitosis
  • Segregation of genes
    • Independent assortment
    • Linkage
    • Recombination
      • Single crossovers
      • Double crossovers
      • Synaptonemal complex
      • Tetrad
    • Sex-linked characteristics
    • Very few genes on Y chromosome
    • Sex determination
    • Cytoplasmic/extranuclear inheritance
  • Mutation
    • General concept of mutation — error in DNA sequence
    • Types of mutations: random, translation error, transcription error, base substitution, inversion, addition, deletion, translocation, mispairing
    • Advantageous vs. deleterious mutation
    • Inborn errors of metabolism
    • Relationship of mutagens to carcinogens
  • Genetic drift
  • Synapsis or crossing-over mechanism for increasing genetic diversity
NA NA
  • Ch. 25 DNA Replication, Repair, and Recombination, pp. 879-937
  • Ch. 23 The Reproductive Systems, pp. 811-813
  • Ch. 14 Cell Division, pp. 539-581
Analytic Methods (BIO)
  • Hardy-Weinberg Principle
  • Test cross
  • Gene mapping: crossover frequencies
  • Biometry: statistical methods
NA NA NA NA
  • Ch. 10 The Nature of the Gene and the Genome, pp. 370-373
Evolution (BIO)
  • Natural selection
    • Fitness concept
    • Selection by differential reproduction
    • Concepts of natural and group selection
    • Evolutionary success as increase in percentage representation in the gene pool of the next generation
  • Speciation
    • Polymorphism
    • Adaptation and specialization
    • Inbreeding
    • Outbreeding
    • Bottlenecks
  • Evolutionary time as measured by gradual random changes in genome
NA NA
  • Ch. 1 Introduction to the Chemistry of Life, pp. 1-22
NA
  • Ch. 2 The Chemical Basis of Life, pp. 76-77
  • Ch. 10 The Nature of the Gene and the Genome, pp. 394-395
Principles of Bioenergetics (BC, GC)
  • Bioenergetics/thermodynamics
    • Free energy/Keq
      • Equilibrium constant
      • Relationship of the equilibrium constant and ΔG°
    • Concentration
      • Le Châtelier’s Principle
    • Endothermic/exothermic reactions
    • Free energy: G
    • Spontaneous reactions and ΔG°
  • Phosphoryl group transfers and ATP
    • ATP hydrolysis ΔG << 0
    • ATP group transfers
  • Biological oxidation-reduction
    • Half-reactions
    • Soluble electron carriers
  • Flavoproteins
  • Ch. 8 Enzymes: Basic Concept and Kinetics, pp. 236-241
  • Ch. 15 Metabolism: Basic Concepts and Design, pp. 463-486
  • Ch. 18 Oxidative Phosphorylation, pp. 576-582
  • Ch. 6 Basic Concepts of Enzyme Action, pp. 108-114
  • Ch. 15 Metabolism: Basic Concepts and Designs, pp. 287-292
  • Ch. 20 The Electron Transport Chain, pp. 402-413
  • Ch. 12 Enzyme Kinetics, Inhibition, and Control, pp. 361-401
  • Ch. 4 Metabolism, pp. 100-113
  • Ch. 3 Bioenergetics, Enzymes, and Metabolism
Carbohydrates (BC, OC)
  • Description
    • Nomenclature and classification, common names
    • Absolute configuration
    • Cyclic structure and conformations of hexoses
    • Epimers and anomers
  • Hydrolysis of the glycoside linkage
  • Monosaccharides
  • Disaccharides
    • Polysaccharides
  • Ch. 11 Carbohydrates, pp. 341-365
  • Ch. 10 Carbohydrates, pp. 181-201
  • Ch. 8 Carbohydrates, pp. 221-244
  • Ch. 2 Chemical Composition of the Body, pp. 37-40
  • Ch. 4 Metabolism, pp. 113-121
  • Ch. 2 The Chemical Basis of Life, pp. 41-46