Content Category 2C: Processes of cell division, differentiation, and specialization

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The ability of organisms to reproduce their own kind is the characteristic that best distinguishes living things. In sexually reproducing organisms, the continuity of life is based on the processes of cell division and meiosis. 

The process of cell division is an integral part of the cell cycle. The progress of eukaryotic cells through the cell cycle is regulated by a complex molecular control system. Malfunctions in this system can result in unabated cellular division, and ultimately the development of cancer. 

In the embryonic development of multicellular organisms, a fertilized egg gives rise to cells that differentiate into many different types of cells, each with a different structure, corresponding function, and location within the organism. During development, spatial-temporal gradients in the interactions between gene expression and various stimuli result in the structural and functional divergence of cells into specialized structure, organs, and tissues. The interaction of stimuli and genes is also explained by the progression of stem cells to terminal cells. 

The content in this category covers the cell cycle; the causes, genetics, and basic properties of cancer; the processes of meiosis and gametogenesis; and the mechanisms governing cell specialization and differentiation. 

Topic Biochemistry Biochemistry: A Short Course Biology, 2e Fundamentals of Biochemistry Human Physiology Karp’s Cell and Molecular Biology
Mitosis (BIO)
  • Mitotic process: prophase, metaphase, anaphase, telophase, interphase
  • Mitotic structures
    • Centrioles, asters, spindles
    • Chromatids, centromeres, kinetochores
    • Nuclear membrane breakdown and reorganization
    • Mechanisms of chromosome movement
  • Phases of cell cycle: G0, G1, S, G2, M
  • Growth arrest
  • Control of cell cycle
  • Loss of cell-cycle controls in cancer cells
NA NA NA
  • Ch. 3 Cells, pp. 79-83
  • Ch. 14 Cell Division
Biosignalling (BC)
  • Oncogenes, apoptosis
  • Ch. 14 Signal-Transduction Pathways, pp. 455-457
  • Ch. 13 Signal-Transduction Pathways, pp. 245-261
  • Ch. 13 Biochemical Signaling, pp. 402 - 441
  • Ch. 3 Cells, p. 82
  • Ch. 16 Cancer
Reproductive System (BIO)
  • Gametogenesis by meiosis
  • Ovum and sperm
    • Differences in formation
    • Differences in morphology
    • Relative contribution to next generation
  • Reproductive sequence: fertilization, implantation, development, birth
NA NA NA
  • Ch. 23 The Reproductive Systems, pp. 811-816, 823-827
  • Ch. 14 Cell Division, pp. 539-581
Embryogenesis (BIO)
  • Stages of early development (order and general features of each)
    • Fertilization
    • Cleavage
    • Blastula formation
    • Gastrulation
      • First cell movements
      • Formation of primary germ layers (endoderm, mesoderm, ectoderm)
    • Neurulation
  • Major structures arising out of primary germ layers
  • Neural crest
  • Environment-gene interaction in development
NA NA NA
  • Ch. 23 The Reproductive Systems, pp. 840-851
NA
Mechanisms of Development (BIO)
  • Cell specialization
    • Determination
    • Differentiation
    • Tissue types
  • Cell-cell communication in development
  • Cell migration
  • Pluripotency: stem cells
  • Gene regulation in development
  • Programmed cell death
  • Existence of regenerative capacity in various species
  • Senescence and aging
NA NA NA NA
  • Ch. 1 An Introduction to Physiology, pp. 5-6
  • Ch. 23 The Reproductive Systems, p. 839
  • Ch. 7 Interactions Between Cells and Their Environment, pp. 226-234
  • Ch. 15 Cell Signaling and Signal Transduction: Communication Between Cells, pp. 621-625