Foundational Concept 3

Foundational Concept 3

Complex systems of tissues and organs sense the internal and external environments of multicellular organisms, and through integrated functioning, maintain a stable internal environment within an ever-changing external environment.  

Content Categories:

nibrown@aamc.org

Content Category 3A: Structure and functions of the nervous and endocrine systems and ways in which these systems coordinate the organ systems

Content Category 3A: Structure and functions of the nervous and endocrine systems and ways in which these systems coordinate the organ systems

The nervous and endocrine systems work together to detect external and internal signals, transmit and integrate information, and maintain homeostasis. They do all of this by producing appropriate responses to internal and external cues and stressors. The integration of these systems both with one another, and with the other organ systems, ultimately results in the successful and adaptive behaviors that allow for the propagation of the species. 

Animals have evolved a nervous system that senses and processes internal and external information that is used to facilitate and enhance survival, growth, and reproduction. The nervous system interfaces with sensory and internal body systems to coordinate physiological and behavioral responses ranging from simple movements and small metabolic changes to long-distance migrations and social interactions. The physiological processes for nerve signal generation and propagation involve specialized membranes with associated proteins that respond to ligands and/or electrical field changes, signaling molecules and, by extension, the establishment and replenishment of ionic electrochemical gradients requiring ATP. 

The endocrine system of animals has evolved to produce chemical signals that function internally to regulate stress responses, reproduction, development, energy metabolism, growth, and various individual and interactive behaviors. The integrated contributions of the nervous and endocrine systems to bodily functions are exemplified by the process whereby the signaling of neurons regulates hormone release, and by the targeting of membrane or nuclear receptors on neurons by circulating hormones.  

The content in this category covers the structure, function, and basic aspects of nervous and endocrine systems, and their integration. The structure and function of nerve cells is also included in this category. 

Topic Biochemistry Biochemistry: A Short Course Biology, 2e Fundamentals of Biochemistry Human Physiology Karp’s Cell and Molecular Biology
Nervous System: Structure and Function (BIO)
  • Major Functions
    • High level control and integration of body systems
    • Adaptive capability to external influences
  • Organization of vertebrate nervous system
  • Sensor and effector neurons
  • Sympathetic and parasympathetic nervous systems: antagonistic control
  • Reflexes
    • Feedback loop, reflex arc
    • Role of spinal cord and supraspinal circuits
  • Integration with endocrine system: feedback control
NA NA NA NA
  • Ch. 7 The Nervous System and Neuronal Excitability, pp. 191-193
  • Ch. 10 Autonomic and Somatic Nervous Systems
  • Ch. 4 The Structure and Function of the Plasma Membrane, pp. 158-167
Nerve Cell (BIO)
  • Cell body: site of nucleus, organelles
  • Dendrites: branched extensions of cell body
  • Axon: structure and function
  • Myelin sheath, Schwann cells, insulation of axon
  • Nodes of Ranvier: propagation of nerve impulse along axon
  • Synapse: site of impulse propagation between cells
  • Synaptic activity: transmitter molecules
  • Resting potential: electrochemical gradient
  • Action potential
    • Threshold, all-or-none
    • Sodium/potassium pump
  • Excitatory and inhibitory nerve fibers: summation, frequency of firing
  • Glial cells, neuroglia
NA NA NA
  • Ch. 7 The Nervous System and Neuronal Excitability, pp. 193-223
  • Ch. 4 The Structure and Function of the Plasma Membrane, pp. 118-119, 158-167
Biosignalling (BC)
  • Gated ion channels
    • Voltage gated
    • Ligand gated
  • Receptor enzymes
  • G protein-coupled receptors
  • Ch. 13 Membrane Channels and Pumps, pp. 403-431
  • Ch. 14 Signal-Transduction Pathways, pp. 437-459
  • Ch. 12 Membrane Structure and Function, pp. 231-239
  • Ch. 13 Signal-Transduction Pathways, pp. 245-261
  • Ch. 13 Biochemical Signaling, pp. 402-441
  • Ch. 6 Cell Signaling, pp. 169-185
  • Ch. 7 The Nervous System and Neuronal Excitability, pp. 201-202
  • Ch. 4 The Structure and Function of the Plasma Membrane, pp. 143-151
  • Ch. 15 Cell Signaling and Cell Transduction: Communication Between Cells pp. 582-598
Lipids (BC, OC)
  • Description; structure
    • Steroids
    • Terpenes and terpenoids
  • Ch. 26 The Biosynthesis of Membrane Lipids and Steroids, pp. 858-882
  • Ch. 29 Lipid Synthesis: Storage Lipids, Phospholipids and Cholesterol, pp. 577-601
  • Ch. 9 Lipids and Biological Membranes, pp. 245-292
  • Ch. 2 Chemical Composition of the Body, pp. 40-45
  • Ch. 2 The Chemical Basis of Life, pp. 46-49
Endocrine System: Hormones and Their Sources (BIO)
  • Function of endocrine system: specific chemical control at cell, tissue, and organ level
  • Definitions of endocrine gland, hormone
  • Major endocrine glands: names, locations, products
  • Major types of hormones
  • Neuroendrocrinology ― relation between neurons and hormonal systems
NA NA NA
  • Ch. 13 The Endocrine System, pp. 448-456
NA
Endocrine System: Mechanisms of Hormone Action (BIO)
  • Cellular mechanisms of hormone action
  • Transport of hormones: blood supply
  • Specificity of hormones: target tissue
  • Integration with nervous system: feedback control regulation by second messengers
NA NA
  • Ch. 22 Mammalian Fuel Metabolism: Integration and Regulation: Section 2. Hormonal Control of Fuel Metabolism, pp. 781-785
  • Ch. 13 The Endocrine System, pp. 448-456
  • Ch. 15 Cell Signaling and Cell Transduction: Communication Between Cells, pp. 583-586, 599-602
nibrown@aamc.org

Content Category 3B: Structure and integrative functions of the main organ systems

Content Category 3B: Structure and integrative functions of the main organ systems

Animals use a number of highly-organized and integrated organ systems to carry out the necessary functions associated with maintaining life processes. Within the body, no organ system is an island. Interactions and coordination between organ systems allow organisms to engage in the processes necessary to sustain life. For example, the organs and structures of the circulatory system carry out a number of functions, such as transporting:  

  • nutrients absorbed in the digestive system;  

  • gases absorbed from the respiratory system and muscle tissue; 

  • hormones secreted from the endocrine system; and  

  • blood cells produced in bone marrow to and from cells in the body to help fight disease.  

The content in this category covers the structure and function of the major organ systems of the body including the respiratory, circulatory, lymphatic, immune, digestive, excretory, reproductive, muscle, skeletal, and skin systems. Also covered in this category is the integration of these systems and their control and coordination by the endocrine and nervous systems. 

Topic Biochemistry Biology, 2e Human Physiology Karp’s Cell and Molecular Biology
Respiratory System (BIO)
  • General function
    • Gas exchange, thermoregulation
    • Protection against disease: particulate matter
  • Structure of lungs and alveoli
  • Breathing mechanisms
    • Diaphragm, rib cage, differential pressure
    • Resiliency and surface tension effects
  • Thermoregulation: nasal and tracheal capillary beds; evaporation, panting
  • Particulate filtration: nasal hairs, mucus/cilia system in lungs
  • Alveolar gas exchange
    • Diffusion, differential partial pressure
    • Henry’s Law (GC)
  • pH control
  • Regulation by nervous control
    • CO2 sensitivity
NA
  • Ch. 18 The Respiratory System
  • Ch. 5 Aerobic Respiration and the Mitochondrion, p. 168
  • Ch. 9 The Cytoskeleton and Cell Motility, pp. 327-334
Circulatory System (BIO)
  • Functions: circulation of oxygen, nutrients, hormones, ions and fluids, removal of metabolic waste
  • Role in thermoregulation
  • Four-chambered heart: structure and function
  • Endothelial cells
  • Systolic and diastolic pressure
  • Pulmonary and systemic circulation
  • Arterial and venous systems (arteries, arterioles, venules, veins)
    • Structural and functional differences
    • Pressure and flow characteristics
  • Capillary beds
    • Mechanisms of gas and solute exchange
    • Mechanism of heat exchange
    • Source of peripheral resistance
  • Composition of blood
    • Plasma, chemicals, blood cells
    • Erythrocyte production and destruction; spleen, bone marrow
    • Regulation of plasma volume
  • Coagulation, clotting mechanisms
  • Oxygen transport by blood
    • Hemoglobin, hematocrit
    • Oxygen content
    • Oxygen affinity
    • Oxygen transport by blood; modification of oxygen affinity
  • Carbon dioxide transport and level in blood
  • Nervous and endocrine control
NA
  • Ch. 14 The Cardiovascular System: The Heart
  • Ch. 15 The Cardiovascular System: Blood Vessels and Hemodynamics
  • Ch. 16 The Cardiovascular System: The Blood
NA
Lymphatic System (BIO)
  • Structure of lymphatic system
  • Major functions
    • Equalization of fluid distribution
    • Transport of proteins and large glycerides
    • Production of lymphocytes involved in immune reactions
    • Return of materials to the blood
NA NA
  • Ch. 17 The Immune System, pp. 613-615
  • Ch. 17 The Immune Response, pp. 688-691
Immune System (BIO)
  • Innate (nonspecific) vs. adaptive (specific) immunity
  • Adaptive immune system cells
    • T-lymphocytes
    • B-lymphocytes
  • Innate immune system cells
    • Macrophages
    • Phagocytes
  • Concept of antigen and antibody
  • Antigen presentation
  • Clonal selection
  • Antigen-antibody recognition
  • Structure of antibody molecule
  • Recognition of self vs. nonself, autoimmune diseases
  • Major histocompatibility complex

NA

  • Ch. 17 The Immune System, pp. 615-645
  • Ch. 17 The Immune Response
Digestive System (BIO)
  • Ingestion
    • Saliva as lubrication and source of enzymes
    • Ingestion; esophagus, transport function
  • Stomach
    • Storage and churning of food
    • Low pH, gastric juice, mucal protection against self-destruction
    • Production of digestive enzymes, site of digestion
    • Structure (gross)
  • Liver
    • Structural relationship of liver within gastrointestinal system
    • Production of bile
    • Role in blood glucose regulation, detoxification
  • Bile
    • Storage in gall bladder
    • Function
  • Pancreas
    • Production of enzymes
    • Transport of enzymes to small intestine
  • Small Intestine
    • Absorption of food molecules and water
    • Function and structure of villi
    • Production of enzymes, site of digestion
    • Neutralization of stomach acid
    • Structure (anatomic subdivisions)
  • Large Intestine
    • Absorption of water
    • Bacterial flora
    • Structure (gross)
  • Rectum: storage and elimination of waste, feces
  • Muscular control
    • Peristalsis
  • Endocrine control
    • Hormones
    • Target tissues
  • Nervous control: the enteric nervous system
NA
  • Ch. 21 The Digestive System
  • Ch. 1 Introduction to the Study of Cell and Molecular Biology, pp. 3-5
  • Ch. 15 Cell Signaling and Cell Transduction: Communication Between Cells, pp. 599-602
Excretory System (BIO)
  • Roles in homeostasis
    • Blood pressure
    • Osmoregulation
    • Acid-base balance
    • Removal of soluble nitrogenous waste
  • Kidney structure
    • Cortex
    • Medulla
  • Nephron structure
    • Glomerulus
    • Bowman’s capsule
    • Proximal tubule
    • Loop of Henle
    • Distal tubule
    • Collecting duct
  • Formation of urine
    • Glomerular filtration
    • Secretion and reabsorption of solutes
    • Concentration of urine
    • Counter-current multiplier mechanism
  • Storage and elimination: ureter, bladder, urethra
  • Osmoregulation: capillary reabsorption of H2O, amino acids, glucose, ions
  • Muscular control: sphincter muscle
NA
  • Ch. 19 The Urinary System
  • Ch. 20 Fluid, Electrolyte, and Acid-Base Homeostasis
NA
Reproductive System (BIO)
  • Male and female reproductive structures and their functions
  • Gonads
  • Genitalia
  • Differences between male and female structures
  • Hormonal control of reproduction
  • Male and female sexual development
  • Female reproductive cycle
  • Pregnancy, parturition, lactation
  • Integration with nervous control
NA
  • Ch. 23 The Reproductive Systems
NA
Muscle System (BIO)
  • Important functions
    • Support: mobility
    • Peripheral circulatory assistance
    • Thermoregulation (shivering reflex)
  • Structure of three basic muscle types: striated, smooth, cardiac
  • Muscle structure and control of contraction
    • T-tubule system
    • Contractile apparatus
    • Sarcoplasmic reticulum
    • Fiber type
    • Contractile velocity of different muscle types
  • Regulation of cardiac muscle contraction
  • Oxygen debt: fatigue
  • Nervous control
    • Motor neurons
    • Neuromuscular junction, motor end plates
    • Sympathetic and parasympathetic innervation
    • Voluntary and involuntary muscles
NA
  • Ch. 11 Muscle
  • Ch. 12 Control of Body Movement
  • Ch. 4 The Structure and Function of the Plasma Membrane, pp. 162-167
  • Ch. 9 The Cytoskeleton and Cell Motility, pp. 345-352
Specialized Cell-Muscle Cell (BIO)
  • Structural characteristics of striated, smooth, and cardiac muscle
  • Abundant mitochondria in red muscle cells: ATP source
  • Organization of contractile elements: actin and myosin filaments, crossbridges, sliding filament model
  • Sarcomeres: “I” and “A” bands, “M” and “Z” lines, “H” zone
  • Presence of troponin and tropomyosin
  • Calcium regulation of contraction
NA
  • Ch. 11 Muscle
  • Ch. 9 The Cytoskeleton and Cell Motility, pp. 345-352
Skeletal System (BIO)
  • Functions
    • Structural rigidity and support
    • Calcium storage
    • Physical protection
  • Skeletal structure
    • Specialization of bone types, structures
    • Joint structures
    • Endoskeleton vs. exoskeleton
  • Bone structure
    • Calcium/protein matrix
    • Cellular composition of bone
  • Cartilage: structure and function
  • Ligaments, tendons
  • Endocrine control
NA
  • Ch. 13 The Endocrine System, pp. 459-462, 489-492
NA
Skin System (BIO)
  • Structure
    • Layer differentiation, cell types
    • Relative impermeability to water
  • Functions in homeostasis and osmoregulation
  • Functions in thermoregulation
    • Hair, erectile musculature
    • Fat layer for insulation
    • Sweat glands, location in dermis
    • Vasoconstriction and vasodilation in surface capillaries
  • Physical protection
    • Nails, calluses, hair
    • Protection against abrasion, disease organisms
  • Hormonal control: sweating, vasodilation, and vasoconstriction
NA NA
  • Ch. 17 The Immune System, pp. 615-616
NA
nibrown@aamc.org